Sticky egyptians: a technique for assembling genes encoding constrained peptides of variable length

Sticky egyptians: a technique for assembling genes encoding constrained peptides of variable length.

Naturally occurring peptides, such as those produced by the poisonous marine snails of the genus Conus , have the ability to form tight, highly specific molecular interactions. The rigidity of the peptide framework which promotes these interactions is usually maintained by disulphide bonds, and it seems that the overall main chain conformation (or fold) of the peptide is determined by its lengt...

Parallel Variable-Length Encoding on GPGPUs

Variable-Length Encoding (VLE) is a process of reducing input data size by replacing fixed-length data words with codewords of shorter length. As VLE is one of the main building blocks in systems for multimedia compression, its efficient implementation is essential. The massively parallel architecture of modern general purpose graphics processing units (GPGPUs) has been successfully used for ac...

Parallel Variable Distribution Algorithm for Constrained Optimization with Nonmonotone Technique

Self-assembling amphiphilic peptides†

The self-assembly of several classes of amphiphilic peptides is reviewed, and selected applications are discussed. We discuss recent work on the self-assembly of lipopeptides, surfactant-like peptides and amyloid peptides derived from the amyloid-β peptide. The influence of environmental variables such as pH and temperature on aggregate nanostructure is discussed. Enzyme-induced remodelling due...

Identification of Leishmania genes encoding proteins containing tandemly repeating peptides

A genomic Leishmania major DNA expression library was screened using antibodies raised against L. major membranes. Two different clones were identified that encoded proteins containing regions of tandemly repeated peptides. Clone 20 encodes a repetitive peptide of 14 amino acids, while clone 39 encodes a repetitive peptide of 10 amino acids. DNA from clone 20 hybridized with two RNA species of ...